Saint-Domingue (French pronunciation: ​[sɛ̃.dɔ.mɛ̃ɡ]) was a French colony in the western portion of the Caribbean island of Hispaniola, in the area of modern-day Haiti, from 1659 to 1804. The name derives from the Spanish main city on the island, Santo Domingo, which came to refer specifically to the Spanish-held Captaincy General of Santo Domingo, now the Dominican Republic. The borders between the two were fluid and changed over time until they were finally solidified in the Dominican War of Independence in 1844.

The French had established themselves on the western portion of the islands of Hispaniola and Tortuga by 1659. In the Treaty of Ryswick of 1697, Spain formally recognized French control of Tortuga Island and the western third of the island of Hispaniola. In 1791, slaves and some Dominican Creoles took part in a Vodou ceremony at Bois Caïman and planned the Haitian Revolution. The slave rebellion later allied with Republican French forces following the abolition of slavery in the colony in 1793, although this alienated the island's dominant slave-owning class. France controlled the entirety of Hispaniola from 1795 to 1802, when a renewed rebellion began. The last French troops withdrew from the western portion of the island in late 1803, and the colony later declared its independence as Haiti, the Taino Indian name for the island, the following year.